Only few elements were retained (basically names of the ship and crewmen), otherwise no connection with the book.
We are in the future, master phantom, a human turned into a (rather ugly) cyborg, thinks (not so inaccuratly actually, this is what makes the show rather interesting) that humanity left him die and betrayed him. He rebells, and with an army if androids, takes control of the galaxy and earth.
One of the key figures of the human resistance is captain Nemo, a descendant of the original Nemo, commanding a spaceship called the Nautilus, and the show's plot is centred on the Nautilus's missions.
There was only one season out of 26 épisodes. 13 (randomly chosen) were dubbed and aired in the US, in 3D (french version was in 2D). The show had some flaws, but managed to be interesting by its rather original mature story (for a western cartoon), and the combination of 2D and CGI animation, which was rather unusual back then.
The french name of the show was "20000 lieues dans l'espace".
In one episode, the entire crew gets captured and hand, as well as leg cuffed with some kind of amber. One of the crew member is a cute blonde. Sadly, it was one of the 13 épisodes never aired in the US (I say sadly because all 13 US eps are on youtube while the french version is like the holy grail, not re-aired since 20 years, never edited on VHS)
But who knows